If you are referring to the mixture screws then there are only good starting points. The rest is by how the ski responds to any further adjustments. When setting up the low speed circuit, adjust the mixture screw in and listen to the idle. It will increase to a point then start to surge. When you hear that, back the screw out until the fastest idle comes back, then just a shade more to slow it very slightly. Lower your idle speed to around 1200 rpm, that will get your idle circuit figured out. The idle will be proper when you snap the throttle and the ski revs up quick, but returns to idle quickly. If it holds high rpm, too lean, if it falls off and sputters, then comes back up to idle, too rich.
The high speed circuit depends on a few things, but basically start with the mixture screw out about 1 1/4 turns and go for a very short ride. Blip it and see if it bogs or hesitates. Bogging will be sluggish performance and sound like it's drowning, lean will have a rev limiter-like response. Turn in about a 1/16 of a turn for a bog, turn out 1/8 of a turn for a lean hesitation. Try to make it get boggy, boggy won't blow the engine, lean will. Only do short, little laps until you get it close. It only takes a second to hear the difference in clean power and bogs or lean spots.