What size domes are they?
Assuming your compression test is accurate, I would lower to ~220 psi, run race gas, see how you like $10/gallon or what ever it is, and then move from there. What engine are you running? I would be afraid you'd blow your head off at 220 psi with a 650 or 750 engine even. Unless you've done a lot of research and know that people have run that high of compression before and safely, though like I said, in that case it will boil down to if you want to spend $50 on gas per ride by running race gas and then boosting the octane even then (forgive my ignorance if there are different race gas octane levels, never used race gas before).